【発明の名称】ステロイドカルボン酸塩の製造法

Title:

【発明の名称】ステロイドカルボン酸塩の製造法

Document Type and Number:

Japanese Patent JPS5842879

Kind Code:

B2

Abstract:

An alkali metal salt of a 3-(17 beta -hydroxyandrosten-3-one 3-acetal-17 alpha -yl)propiolic acid which is useful as an intermediate in the preparation of 3-(3-oxo-7 alpha -acetylthio-17 beta -hydroxyandrost-4-en-17 alpha -yl)-propiolactone (spironolactone) as antialdosteronic diuretics and hypotensive agents is prepared by reacting a 17 beta -hydroxypregnen-20-yn-3-one 3-acetal (I) with an alkali metal dimsyl (II) to give an alkali metal salt of the 17 beta -hydroxypregnen-20-yn-3-one 3-acetal (III), and reacting the compound (III) with carbon dioxide followed by hydrolysis.

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Inventors:

OKUJIMA HIROMI
FUJIMORI SHINICHIRO
FURUYA RIKIZO
HAYAKAWA SHUZO

Application Number:

JP5896979A

Publication Date:

September 22, 1983

Filing Date:

May 14, 1979

Export Citation:

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Assignee:

MITSUBISHI CHEM IND

International Classes:

C07J21/00; C07J31/00; C07J51/00; (IPC1-7): C07J21/00

Attorney, Agent or Firm:

Hasegawa Hajime

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