Title:
【発明の名称】メタンジホスホン酸誘導体、その製造方法およびその医薬用途
Document Type and Number:
Japanese Patent JPH0826048
Kind Code:
B2
Abstract:
A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R<1>, R<2>, R<3> and R<4> represent each independently hydrogen, C1 to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.
Inventors:
KAWABE NORIO
UCHIRO TAKUMI
NAKADATE AKIO
TANAHASHI MASAHIKO
ITO MASATOSHI
UCHIRO TAKUMI
NAKADATE AKIO
TANAHASHI MASAHIKO
ITO MASATOSHI
Application Number:
JP50423492A
Publication Date:
March 13, 1996
Filing Date:
February 03, 1992
Export Citation:
Assignee:
TORAY INDUSTRIES
International Classes:
A61K31/66; A63C11/22; A63C11/24; C07F9/38; C07F9/40; (IPC1-7): C07F9/38; A61K31/66; C07F9/40
Domestic Patent References:
| JP5942395A | ||||
| JP344328A | ||||
| JP62270593A | ||||
| JP3106893A |
Attorney, Agent or Firm:
Shoichi Ui (4 others)
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