Title:
PROSTAGLANDIN ANALOGOUS FOR MEDICINE
Document Type and Number:
Japanese Patent JPH0687749
Kind Code:
A
Abstract:
PURPOSE: To obtain a compound useful for the prevention and treatment of congestive heart failure. CONSTITUTION: The compound of formula I [W is formula II or formula III (Z is -V(CH2 )b CO2 H; (b) is 1 or 2; V is O when (b) is 1, and methlene when (b) is 2); X is H, cyano, or -C≡CH; dotted line represents optional double bond], e.g. (1R,2R,3as,9as)- [2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((S)-3-hydroxyoctyl)-1H- benz[f]indene-5-yl]oxy}acetic acid. The compound is especially effective against congestive heart failure without pulmonary hypertension. In the manufacture of medicament, the compound of the formula I is included with a ratio of 0.05-95 wt.%, and the daily dose of the compound is 25 μm-250 mg/day/kg.
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Inventors:
UORUKAA ANDAASON RONGU
JIEEMUSU UORUKAA KUROU
JIEEMUSU UORUKAA KUROU
Application Number:
JP22823691A
Publication Date:
March 29, 1994
Filing Date:
May 24, 1991
Export Citation:
Assignee:
WELLCOME FOUND
International Classes:
A61K31/34; A61K31/40; A61K31/557; A61K31/5575; A61K31/635; A61P9/00; C07C405/00; (IPC1-7): A61K31/557
Attorney, Agent or Firm:
Akira Asamura (3 outside)
Next Patent: MEDICINE COMPOSITION