Title:
【発明の名称】強いリガーゼ活性を有する微生物を用いるβ-ラクタム系抗生物質の製造法
Document Type and Number:
Japanese Patent JPH10506287
Kind Code:
A
Abstract:
The present invention relates to the biosynthesis of beta-lactam antibiotics. More specifically, the invention relates to processes of producing beta-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing certain steps involved in beta-lactam biosynthesis. Further, the invention relates to a DNA construct encoding the novel enzyme, a recombinant vector or transformation vehicle comprising the DNA construct, and finally a cell comprising the DNA construct or recombinant vector.
Inventors:
Curse Girl Svend
Christiansen Claus Niegarde
Mail Girl Henrik
Christiansen Claus Niegarde
Mail Girl Henrik
Application Number:
JP51139496A
Publication Date:
June 23, 1998
Filing Date:
September 27, 1995
Export Citation:
Assignee:
Gist Brocades Besloten Fennaught Shap
International Classes:
C12N15/09; C07H21/04; C12N1/15; C12N1/20; C12N1/21; C12N9/00; C12N15/00; C12N15/52; C12N15/80; C12P17/10; C12P17/14; C12P35/00; C12P35/04; C12P35/06; C12P37/00; C12P37/04; C12R1/82; (IPC1-7): C12N15/09; C12N1/15; C12N9/00; C12P35/04; C12P37/04
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)