Title:
【発明の名称】新規なアルケン誘導体の製造法
Document Type and Number:
Japanese Patent JPH0742241
Kind Code:
B2
Abstract:
The invention provides novel compounds of the formula: in wherein m is 1 or 2, R6 and R7, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or wherein n is 0 to 4, R1 and R2 which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, formyloxy, alkylcarbonyloxy of 1 to 4 carbon atoms or CH2R4 is replaced by CHO; R5 is H or OH; or R4 and R5 together form an -O- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumours. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.
Inventors:
Rei Yohani Toibora
Alt Johannes Karjalainen
Kauko Oiba Antero Kurquera
Maruya-Lisa Sodervale
Lauri Batesco Matches Cangas
Guillermo Luis Blanco
Hannes Callervo Sundquist
Alt Johannes Karjalainen
Kauko Oiba Antero Kurquera
Maruya-Lisa Sodervale
Lauri Batesco Matches Cangas
Guillermo Luis Blanco
Hannes Callervo Sundquist
Application Number:
JP28913692A
Publication Date:
May 10, 1995
Filing Date:
October 27, 1992
Export Citation:
Assignee:
Farmos-Yuhichume Oyu
International Classes:
A61K31/047; A61K31/05; A61K31/085; A61K31/135; A61K31/395; A61K31/396; A61P35/00; C07B61/00; C07C11/02; C07C15/16; C07C15/52; C07C17/16; C07C22/04; C07C25/24; C07C29/09; C07C29/10; A61K31/045; C07C29/128; C07C33/26; C07C33/28; C07C37/00; C07C37/20; C07C37/50; C07C37/62; C07C39/12; C07C39/16; C07C39/19; C07C39/21; C07C39/215; C07C39/367; C07C39/373; C07C41/18; C07C41/26; C07C41/30; C07C43/178; C07C43/205; C07C43/225; C07C43/23; C07C43/30; C07C213/08; C07C215/68; C07C217/18; C07C217/80; C07C309/63; C07D203/10; C07D265/30; C07D295/08; C07D295/092; C07D307/06; C07D307/12; C07D307/14; C07D307/20; C07D309/04; C07D309/06; C07D309/12; (IPC1-7): C07C39/21; A61K31/045; A61K31/05; A61K31/085; A61K31/135; C07C37/00; C07C41/18; C07C43/23; C07C213/08; C07C215/68; C07C217/18; C07C217/80; C07D203/10; C07D295/08
Attorney, Agent or Firm:
Keiji Saki (2 outside)
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