Title:
【発明の名称】光学活性な第二アミンの製造方法
Document Type and Number:
Japanese Patent JP2710632
Kind Code:
B2
Abstract:
Optically active secondary amines are prepared by asymmetric hydrogenation of prochiral N-aliphatic ketimines at a temperature of -20 to 80 DEG C, a hydrogen pressure of 10<5> to 10<7> Pa with the addition of catalytic amounts of an iridium compound of the formula III or IIIa… [XIrYZ] (III) or [XLrY]<(+)>A<(-)> (IIIa> in which X represents two olefin ligands or a diene ligand, Y denotes a chiral diphosphine whose secondary phosphine groups are linked by 2-4 carbon atoms and which together with the iridium atom forms a 5-, 6- or 7-membered ring, or Y denotes a chiral diphosphinite whose phosphinite groups are linked via 2 carbon atoms and which together with the iridium atom forms a 7-membered ring, Z represents Cl, Br or I, and A<-> is the anion of an oxo acid or of a complex acid, and, if desired with the addition of an ammonium or alkali metal chloride, bromide or iodide.
Inventors:
Benoit Pugin
Gerald Ramos
Felix Spindler
Gerald Ramos
Felix Spindler
Application Number:
JP18707488A
Publication Date:
February 10, 1998
Filing Date:
July 28, 1988
Export Citation:
Assignee:
Novartis Actien Gezershyaft
International Classes:
B01J31/28; C07B31/00; C07B43/04; C07B53/00; C07B61/00; C07C67/00; C07C209/00; C07C209/52; C07C209/70; C07C211/01; C07C211/08; C07C211/17; C07C211/27; C07C211/58; C07C227/06; C07C229/06; C07C229/14; C07C231/18; C07C237/04; C07C237/06; C07C237/30; C07C237/40; C07C255/24; C07C255/61; C07C313/00; C07C319/20; C07C323/32; C07D209/44; C07D217/02; (IPC1-7): C07B43/04; C07B53/00; C07C209/70; C07C211/01; C07C229/06; C07C237/04; C07C255/24; C07D209/44; C07D217/02
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)