Title:
【発明の名称】テトラヒドロ葉酸化合物の光学異性的に純粋なジアステレオ異性体の製造方法
Document Type and Number:
Japanese Patent JP3027613
Kind Code:
B2
Abstract:
A process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds is described, comprising the conversion, for example, of only the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolate synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative or (radiolabeled) tetrahydrofolic acid or a salt or ester thereof.
Inventors:
Gerhard Schüllingmann
Stiletto Art Alan Rosenfeld
Stiletto Art Alan Rosenfeld
Application Number:
JP40719090A
Publication Date:
April 04, 2000
Filing Date:
December 10, 1990
Export Citation:
Assignee:
American Cyanamid Company
International Classes:
C07D475/04; C12N9/00; C12P17/18; C12P41/00; (IPC1-7): C12P41/00; C12P17/18
Attorney, Agent or Firm:
Heikichi Odashima