Title:
【発明の名称】医薬品グレードのジチオカルバメートの製造方法
Document Type and Number:
Japanese Patent JP2002537234
Kind Code:
A
Abstract:
The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a pharmaceutically acceptable diluent that is a solvent for the carbon disulfide, but not for the secondary amine in an inert gas atmosphere, cooling the mixture so as to precipitate the dithiocarbamate therefrom, and separating the precipitated dithiocarbamate from the cooled mixture. The preferred solvent contains absolute ethanol. In alternative embodiments, the invention further provides methods for purifying a dithiocarbamate to obtain a pharmaceutical-grade dithiocarbamate particulate from a dithiocarbamate feed and methods for producing a sterile pharmaceutical-grade dithiocarbamate from a dithiocarbamate feed.
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Inventors:
Basilev, Basile, Pea
Riau, Way-Chen
Rye, Chin-Sun
Riau, Way-Chen
Rye, Chin-Sun
Application Number:
JP2000599268A
Publication Date:
November 05, 2002
Filing Date:
February 16, 2000
Export Citation:
Assignee:
Medinox, Inc.
International Classes:
A61K31/325; C07C333/16; (IPC1-7): C07C333/16; A61K31/325
Domestic Patent References:
| JPS51139632A | 1976-12-02 | |||
| JPS5069021A | 1975-06-09 | |||
| JPS4983737A | 1974-08-12 |
Foreign References:
| WO1998030660A1 | 1998-07-16 | |||
| US2379965A | 1945-07-10 |
Attorney, Agent or Firm:
Akira Asamura (3 outside)