Title:
【発明の名称】遺伝子毒性変異誘発に対する保護方法
Document Type and Number:
Japanese Patent JPH09506071
Kind Code:
A
Abstract:
A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphosphorothioic acid, S-1-(aminoethyl) phosphorothioic acid, S-Ä2-(3-methylaminopropyl) aminoethylÜ phosphorothioate acid, S-2-(4-aminobu-lamino) ethylphosphorothioic acid, 3-Ä(2-mercaptoethyl) aminoÜ propionamide p-toluenesulfonate, S-1-(2-hydroxy-3-amino) propyl phosphorothioic acid, 2-Ä3-(methylamino) propylaminoÜ ethanethiol, 2-(aminopropylamino)ethanethiol, S-2-(5-aminopentylamino) ethyl phosphorothioic acid, 1 Ä3-(3-(aminopropyl) thiazolidin-2-Y1Ü-D-gluco-1,2,3,4,5 pentanepentol dihydrochloride and N,N'-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamme to the mammal before or up to 3 hours after irradiation.
Inventors:
Gadina, David Jay.
Application Number:
JP50930995A
Publication Date:
June 17, 1997
Filing Date:
September 12, 1994
Export Citation:
Assignee:
Arch Development Corporation
International Classes:
C07D277/04; A61K31/13; A61K31/185; A61K31/425; A61K31/426; A61K31/66; A61K31/661; A61K31/785; A61K45/06; A61P35/00; A61P39/02; A61P43/00; C07C323/25; C07F9/165; C07H5/10; C07H9/06; (IPC1-7): A61K31/66; A61K31/13; A61K31/425; A61K31/785; C07D277/04; C07F9/165
Attorney, Agent or Firm:
Shusaku Yamamoto