Title:
【発明の名称】α,β―不飽和ケトンの立体選択的還元方法
Document Type and Number:
Japanese Patent JP2000502099
Kind Code:
A
Abstract:
A process for the preparation of alpha,beta-unsaturated alcohols of general formula (I),whereinR means an alkyl group of 1-4 carbon atoms, or benzoyloxy group optionally substituted with a phenyl group;R1 means a hydrogen atom or an alkyl group of 1-4 carbon atoms,R2 means a hydrogen atom or an alkyl group of 1-4 carbon atoms;R3 means an alkyl group of 1-6 carbon atoms optionally substituted by phenyl group or cycloalkyl group of 5-7 carbon atoms; or a phenoxy group optionally substituted by a halogen atom, or a cycloalkyl group of 5-7 carbon atoms;R4 means a hydrogen atom or a halogen atomwhereby at alpha,beta-unsaturated ketones of general formula (II) wherein themeanings of R, R1, R2, R3, and R4 are as given above-is diastereoselectively reduced with a borohydride type compound in an aprotic solvent, in the presence of an inorganic substance dissolublein the reaction mixture and having particle size from 0.01 micrometer to 10000 micrometer and optionally from the resulting mixture of epimeric alpha,beta-unsaturated alcohols of general formula (I) and (III)meanings of R, R1, R2, R3, and R4 are as given above-the alpha,beta-unsaturated alcohol of general formula (I) is separated by methods known.
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Inventors:
Barone, Cardos Giyudjanna
Bennur, Nandol
Belle Syune, Povalnyu Magdorna
Djalday
Evin Gel, Catalin
Follau, Larslaw
High jewel, pharrix
Hermets, Ishiyu Toban
Lukats, Geza
Black ore, Carroll
Polykune, Shigetei Catalin
Seveshi Yuchien, Udate
Sabo, Tabor
Severeni Yui, Zoltan
Bayda, Elvin
Baan Kai, Gabor
Boufferii, Pearl
Bennur, Nandol
Belle Syune, Povalnyu Magdorna
Djalday
Evin Gel, Catalin
Follau, Larslaw
High jewel, pharrix
Hermets, Ishiyu Toban
Lukats, Geza
Black ore, Carroll
Polykune, Shigetei Catalin
Seveshi Yuchien, Udate
Sabo, Tabor
Severeni Yui, Zoltan
Bayda, Elvin
Baan Kai, Gabor
Boufferii, Pearl
Application Number:
JP52260597A
Publication Date:
February 22, 2000
Filing Date:
December 18, 1996
Export Citation:
Assignee:
Quinoine, jiocell, essille, vegetation, thermekek, zyara, el, te
International Classes:
C07D307/935; C07D307/83; (IPC1-7): C07D307/935
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)