Title:
【発明の名称】ニコチン性アセチルコリン受容体アゴニストによる、膣乾燥の治療方法
Document Type and Number:
Japanese Patent JP2003533475
Kind Code:
A
Abstract:
The invention provides a method for treating vaginal dryness by increasing hydration and lubrication of vaginal and cervical tissues in a subject in need of such treatment. The method comprises administering to the subject a nicotinic acetylcholine receptor agonist such as nicotine and its analogs, transmetanicotine and its analogs, epibatidine and it analogs, lobeline and its analogs, pyridol derivatives, para-alkylthiophenol derivatives, and imidacloprid and its analogs, in an amount effective to stimulate cervical and vaginal secretions. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the formulation include: topical administration via a liquid, gel, cream, ointment, foam, pessary, or tablet; systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, suppository form, or transdermal form. The invention is useful for treating vaginal dryness and vulvar pain.
Inventors:
Jerusa, Benjamin Earl.
Application Number:
JP2001583756A
Publication Date:
November 11, 2003
Filing Date:
May 09, 2001
Export Citation:
Assignee:
Inspire Pharmaceuticals, Incorporated
International Classes:
A61K31/00; A61K31/40; A61K31/4025; A61K31/42; A61K31/423; A61K31/435; A61K31/44; A61K31/4412; A61K31/4427; A61K31/4439; A61K31/444; A61K31/445; A61K31/465; A61K31/501; A61K45/00; A61P15/00; A61P15/02; C07D487/08; C07D207/08; C07D211/32; C07D213/38; C07D401/04; C07D401/12; C07D413/04; (IPC1-7): A61K45/00; A61K31/40; A61K31/42; A61K31/4439; A61K31/444; A61K31/445; A61K31/465; A61K31/501; A61P15/00; A61P15/02; C07D401/04
Attorney, Agent or Firm:
Takashi Ishida (4 others)