【発明の名称】食細胞の細胞表面タンパク質の付着機能領域に特異的なモノクローナル抗体

Title:

【発明の名称】食細胞の細胞表面タンパク質の付着機能領域に特異的なモノクローナル抗体

Document Type and Number:

Japanese Patent JPH03501560

Kind Code:

A

Abstract:

A hybrid cell line is developed which produces a monoclonal antibody which binds to a unique antigenic site expressed on the surface of phagocytic cells. The monoclonal antibody binds to and activates a specific domain of the CD11b glycoprotein so as to inhibit adhesion dependent functions of the phagocytic cell, but it does not affect other phagocytic functions. This monoclonal antibody can be used as a reactant in an in vitro diagnostic immunoassay for detecting the unique antigenic site on the surface of normal human neutrophils.

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Inventors:

Schlossman Stuart F
Griffin James Dee

Application Number:

JP50416588A

Publication Date:

April 11, 1991

Filing Date:

May 02, 1988

Export Citation:

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Assignee:

Dana-Farber Cancer Institute

International Classes:

C07K16/28; C12N5/10; C12N15/02; C12P21/08; G01N33/53; G01N33/577; C12R1/91; (IPC1-7): C12N5/24; C12N15/06; C12P21/08; G01N33/53; G01N33/577

Other References:

J.IMMUNOL.=1986
J.IMMUNOL.=1987

Attorney, Agent or Firm:

Akihide Sugimura (1 outside)

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