Title:
【発明の名称】最終分化に有効な新規誘発物質およびその使用方法
Document Type and Number:
Japanese Patent JPH04500359
Kind Code:
A
Abstract:
The invention provides a class of compounds having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concerns a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation. Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
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Inventors:
Marks, Paul A.
Rifkind, Richard A
Breslow, Ronald
Rifkind, Richard A
Breslow, Ronald
Application Number:
JP50184490A
Publication Date:
January 23, 1992
Filing Date:
November 14, 1989
Export Citation:
Assignee:
The Trustees of Columbia University in the City of New York
Sloan-Kettering Institut for Future Researcher
Sloan-Kettering Institut for Future Researcher
International Classes:
C07D243/06; A61K31/415; A61K31/505; A61P35/00; C07C233/05; C07C233/36; C07C235/74; C07C243/28; C07C259/06; C07D231/32; C07D231/36; C07D239/62; C07D243/08; (IPC1-7): A61K31/415; A61K31/505; C07C233/05; C07C233/36; C07D231/36; C07D239/62; C07D243/06
Attorney, Agent or Firm:
Yoshio Kawaguchi