Title:
【発明の名称】耐腫瘍活性を有する新規な1-アルキル-1-スルホニル-2-アルコキシカルボニルスルフェニルヒドラジン
Document Type and Number:
Japanese Patent JP2686961
Kind Code:
B2
Abstract:
Compounds of the formula: wherein R1 is a lower alkyl of 1-6 carbon atoms, benzyl, phenyl or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino, or carbonyl substituents, or -RN(R min )2 wherein R and R min are each independently alkyl of 1 to 4 carbon atoms; R2 is a heterocycle or an aromatic substituent and each A is an aromatic substitution independently selected from the group consisting of hydrogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, halogen, -NO2, -NH2, -COOH, and -NHCOCH3. The compounds have been found to be alkylating agents having antineoplastic activity for use in inhibiting the growth of tumors.
Inventors:
Alan Sea Sartreli
Krishna Mercy Siam
Robert Tay Fulbiac
Krishna Mercy Siam
Robert Tay Fulbiac
Application Number:
JP13715788A
Publication Date:
December 08, 1997
Filing Date:
June 03, 1988
Export Citation:
Assignee:
YALE UNIVERSITY
International Classes:
A61K31/18; A61K31/33; A61K31/38; A61K31/381; A61K31/415; A61K31/42; A61K31/47; A61P35/00; A61K31/265; C07C311/14; C07C329/02; C07D215/36; C07D231/18; C07D261/10; C07D333/34; C07D521/00; (IPC1-7): C07D215/36; A61K31/38; A61K31/415; A61K31/42; A61K31/47; C07D231/18; C07D261/10; C07D333/34
Attorney, Agent or Firm:
Akimoto Teruo