Title:
【発明の名称】新規なO-アリールメチル-N-(チオ)アシルヒドロキシルアミン、その製造方法及びそれを含有する薬学的組成物
Document Type and Number:
Japanese Patent JP2839468
Kind Code:
B2
Abstract:
O-Aryl methyl N-acyl or N-thioacyl hydroxylamine derivs. of formula ArCH2ON(R1)C(=X)R2 (I), their enantiomers and diastereoisomers are new. X = O or S; R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl; R2 = R21 or R22; R21 = H or alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl all of which may be substd.; R22 = alkylamino, cycloalkylamino, or cycloalkylalkylamino which may be substd. on the (cyclo)alkyl gps.; Ar = naphthyl, indolyl, benzofuranyl, or benzothiophenyl, all of which may be partially or fully hydrogenated. alkyl, alkoxy = 1-6C, alkenyl, alkynyl = 2-6C, cycloalkyl = 3-8C, and opt. substits. on these may be halo, alkyl or alkoxy. Opt. substits. on Ar gps. are one or more gps. R; R = halo, OH, Ra, -CH2Ra, -O-Ra, -CO-Ra or -O-CO-Ra; Ra = opt. substd. alkyl, alkenyl, alkynyl, opt. substd. cycloalkyl, opt. substd. cycloalkylalkyl, opt. substd. aryl or opt. substd. aralkyl; the substits. on aryl and aralkyl gps. may be halo, alkyl, alkoxy, OH and/or haloalkyl.
Inventors:
JAN ANDORIO
MITSUSHERU RANGUROWA
PIEERU RENAARU
FUIRITSUPU DORAGURANJU
MITSUSHERU RANGUROWA
PIEERU RENAARU
FUIRITSUPU DORAGURANJU
Application Number:
JP27876195A
Publication Date:
December 16, 1998
Filing Date:
October 26, 1995
Export Citation:
Assignee:
ADEIIRU
International Classes:
A61K31/16; A61K31/17; A61K31/22; A61K31/34; A61K31/343; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61P25/20; A61P25/24; A61P25/26; C07C259/06; C07C259/08; C07C275/64; C07C327/56; C07C335/40; C07D209/12; C07D307/80; C07D333/56; (IPC1-7): C07C335/40; A61K31/16; A61K31/17; A61K31/22; A61K31/34; A61K31/38; A61K31/40; C07C259/06; C07C327/56; C07D209/12; C07D307/80; C07D333/56
Attorney, Agent or Firm:
Hajime Tsukuni (2 outside)