Title:
【発明の名称】成長ホルモン分泌促進物質としての新規なアミド誘導体
Document Type and Number:
Japanese Patent JP2002542151
Kind Code:
A
Abstract:
Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R 1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is -CO- or -SO 2 -, Y is a substituted or unsubstituted group of Formula (II).
R 2 is hydrogen, or substituted or unsubstituted alkyl, R 3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substitued or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
Inventors:
Nobuo Ishiyama
Hirohide Ishige
Mitsuo Mimura
Tadashi Okuno
Seiji Ukai
Takeshi Kiyoto
Shinji Tauchi
Kiyoshi Iguchi
Juan Pin
Low Guilda H
Hirohide Ishige
Mitsuo Mimura
Tadashi Okuno
Seiji Ukai
Takeshi Kiyoto
Shinji Tauchi
Kiyoshi Iguchi
Juan Pin
Low Guilda H
Application Number:
JP2000599413A
Publication Date:
December 10, 2002
Filing Date:
February 17, 2000
Export Citation:
Assignee:
Kaken Pharmaceutical Co., Ltd.
Molecular Research Institute
Molecular Research Institute
International Classes:
C07D211/60; A61K31/16; A61K31/165; A61K31/167; A61K31/18; A61K31/27; A61K31/445; A61K38/00; A61P1/04; A61P3/04; A61P3/10; A61P7/00; A61P11/00; A61P13/12; A61P15/00; A61P15/08; A61P17/02; A61P19/02; A61P19/10; A61P21/00; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P31/18; A61P35/00; A61P37/00; A61P43/00; C07C231/02; C07C237/12; C07C237/22; C07C237/42; C07C269/06; C07C271/24; C07C303/40; C07C311/07; C07C311/08; C07C311/21; C07D211/62; C07D211/96; C07K5/02; C07K5/06; C07K5/065; C07K5/078; (IPC1-7): C07C237/12; A61K31/16; A61K31/165; A61K31/167; A61K31/18; A61K31/27; A61K31/445; A61K38/00; A61P1/04; A61P3/04; A61P3/10; A61P7/00; A61P11/00; A61P13/12; A61P15/00; A61P15/08; A61P17/02; A61P19/02; A61P19/10; A61P21/00; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P31/18; A61P35/00; A61P37/00; A61P43/00; C07C231/02; C07C237/22; C07C237/42; C07C269/06; C07C271/24; C07C303/40; C07C311/07; C07C311/08; C07C311/21; C07D211/60; C07D211/62; C07D211/96; C07K5/078
Domestic Patent References:
| JPH10509152A | 1998-09-08 | |||
| JPH09507217A | 1997-07-22 | |||
| JPH06263737A | 1994-09-20 |
Attorney, Agent or Firm:
Atsushi Kamata (2 outside)