Title:
【発明の名称】新規の二環式芳香族化合物とそれを含有する医薬用および化粧品用の組成物
Document Type and Number:
Japanese Patent JP2672279
Kind Code:
B2
Abstract:
Bicyclic aromatic cpds. of formula (I), their salts and chiral analogues, are new. R1 = H, -CH3, -CH2-O-R3, -CH2-O-CO-R4, -O-R5, -O-(CH2)m-(CO)n-R6, -CO-R7, -CO-O-R8 or -S(O)p-R9, R2 = H, halo, lower alkyl, -NO2, -O-COR4, -OR9 or -N(R9)R10, Ar = a gp. of formula (a)-(e), X = -O-, -S(O)t or -NR9-, Y, Z = -O-, -S(O)t or -CR11R12, but are not both -O- or -S(O)t, m = 1-3, n = 0 or 1, p = 0, 1-3, t = 0, 1 or 2; R3, R5, R9, R10, R11, R12 = H or lower alkyl, R4 = lower alkyl, R5 = lower alkyl or heterocyclic radical, R7 = H, lower alkyl or -N(R')R", R', R" = H, lower alkyl, mono- or poly-hydroxyalkyl, aryl (opt. substd.) or an aminoacid, sugar or peptide residue, or R'+R" = heterocyclic gp., R8 = H, 1-20C alkyl, alkenyl, mono- or poly-hydroxyalkyl, aryl or aralkyl (opt. substd.) or an aminoacid, sugar or peptide residue.
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Inventors:
Jean-Michel Bernardon
Application Number:
JP10151295A
Publication Date:
November 05, 1997
Filing Date:
April 25, 1995
Export Citation:
Assignee:
Say Yale de Galderma
International Classes:
A61K8/00; A61K8/06; A61K8/14; A61K8/18; A61K8/19; A61K8/25; A61K8/30; A61K8/33; A61K8/36; A61K8/362; A61K8/368; A61K8/37; A61K8/41; A61K8/42; A61K8/44; A61K8/46; A61K8/49; C07D333/38; A61K8/67; A61K8/72; A61K31/06; A61K31/085; A61K31/12; A61K31/135; A61K31/19; A61K31/22; A61K31/255; A61K31/38; A61K31/381; A61K31/44; A61K45/06; A61P9/00; A61P11/00; A61P17/00; A61P17/02; A61P17/04; A61P17/08; A61P17/10; A61P27/02; A61P29/00; A61P35/00; A61Q5/00; A61Q5/02; A61Q5/12; A61Q19/00; A61Q19/08; C07C43/257; C07C47/575; C07C49/255; C07C49/84; C07C63/64; C07C65/26; C07C69/157; C07C69/16; C07C69/24; C07C69/28; C07C69/92; C07C205/36; C07C211/54; C07C317/14; C07C317/18; C07C317/22; C07C317/24; C07C323/62; C07D213/70; C07D213/78; C07D327/06; C07D333/40; (IPC1-7): C07C43/257; A61K7/00; A61K7/48; C07C49/255; C07C49/84; C07C69/157; C07C69/16; C07C69/24; C07C69/28; C07C69/92; C07C205/36; C07C211/54; C07C317/18; C07C317/22; C07C317/24; C07D213/78; C07D333/38
Other References:
【文献】JOURNAL OF MEDICINAL CHEMISTRY,1994,VOL.37,NO.10,P.1508-P.1517
Attorney, Agent or Firm:
Masatake Shiga (2 outside)