【発明の名称】甲状腺ホルモンと類似した作用をする新規化合物 - Smith Kline and French Laboratories Limited

Title:

【発明の名称】甲状腺ホルモンと類似した作用をする新規化合物

Document Type and Number:

Japanese Patent JPH07103070

Kind Code:

B2

Abstract:

Compounds of structure (I) in which, R<1> is -CH2CR<2>R<3>NR<4>R<5> or YCOR<6>; R<2> is hydrogen or C1-4alkyl; R<3> is hydrogen or -COR<6>; R<4> is hydrogen or C1-4alkyl; R<5> is hydrogen, C1-4alkyl or C1-4alkanoyl; R<6> is hydroxy, C1-4alkoxy, or -NR<4>R<5>; Y is a bond or C1-4alkylene; R<7> and R<8> are the same or different and are each hydrogen, halogen, C1-4alkyl, nitro or amino; X is oxygen, sulphur, or CH2; R<9> is hydroxy or a bioprecursor theri20; R<1><0> is hydrogen or C1-4alkyl; and Ar is 4-hydroxyphenyl, 5-hydroxy-2-pyridyl, 6-oxo-3(1H)-pyridyl or a 6-oxo-3(1H)-pyridazinyl group and pharmaceutically acceptable salts thereof, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as antihyperlipidaemic agents.

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Inventors:

Paul Davidson Leeson
Jiyoung Colin Emmett
Anthony Hubbert Underwood
David Elise

Application Number:

JP880086A

Publication Date:

November 08, 1995

Filing Date:

January 18, 1986

Export Citation:

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Assignee:

Smith Kline and French Laboratories Limited

International Classes:

A61K31/135; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/44; A61K31/4418; A61K31/50; A61P3/06; A61P5/12; C07C45/67; C07C45/71; C07C51/00; C07C59/13; C07C65/105; C07C65/24; C07C67/00; C07C69/94; C07C201/00; C07C205/38; C07C205/56; C07C205/57; C07C213/00; C07C215/74; C07C231/00; C07C231/12; C07C233/13; C07C233/18; C07C233/36; C07C233/47; C07C235/46; C07C237/30; C07C255/37; C07C255/44; C07C313/00; C07C323/37; C07C323/62; C07C331/32; C07D213/64; C07D213/65; C07D237/12; C07D237/14; C07D413/12; (IPC1-7): C07C65/105; A61K31/135; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/44; A61K31/50; C07C65/24; C07C69/94; C07C205/38; C07C205/56; C07C205/57; C07C215/74; C07C233/13; C07C233/18; C07C233/36; C07C233/47; C07C235/46; C07C237/30; C07C323/37; C07C323/62; C07D213/64; C07D213/65; C07D237/14

Attorney, Agent or Firm:

Aoyama Ryo (2 outside people)

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