【発明の名称】新規ヒドロゲル単離コクリエート製剤、その調製方法および生物学的関連分子投与のための用途

Japanese Patent JP2002535267

A

A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.

The riff Leila
Jin Tsuo
Segara Ignacio
Manino Raphael

JP2000594446A

October 22, 2002

January 24, 2000

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Bio Delivery Science, Inc.
University of Medicine and Dentistry of New Jersey

C07D233/60; A61K9/00; A61K9/127; A61K31/05; A61K31/192; A61K31/198; A61K31/216; A61K31/337; A61K31/405; A61K31/4174; A61K31/436; A61K31/4422; A61K31/48; A61K31/522; A61K31/568; A61K31/704; A61K31/7042; A61K31/7048; A61K45/00; A61K47/02; A61K47/24; A61K47/30; A61K47/34; A61K47/36; A61K47/42; A61K47/44; A61P9/10; A61P23/00; A61P25/20; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/06; C07D209/26; C07D211/90; C07D305/00; C07D473/18; C07D519/00; C07J1/00; (IPC1-7): A61K9/127; A61K9/00; A61K31/05; A61K31/192; A61K31/198; A61K31/216; A61K31/337; A61K31/405; A61K31/4174; A61K31/436; A61K31/4422; A61K31/48; A61K31/522; A61K31/568; A61K31/704; A61K31/7042; A61K31/7048; A61K45/00; A61K47/02; A61K47/24; A61K47/30; A61K47/34; A61K47/36; A61K47/42; A61K47/44; A61P9/10; A61P23/00; A61P25/20; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/06

JPH11500443A	1999-01-12
JPH04506355A	1992-11-05

JPN5002002432, ＰＡＰＡＨＡＤＪＯＰＯＵＬＯＳ　Ｄ, ＢＩＯＣＨＩＭＩＣＡ　ＥＴ　ＢＩＯＰＨＹＳＩＣＡ　ＡＣＴＡ, 1975, Ｖ３９４　Ｎ３, Ｐ４８３−４９１

Takashi Shoji

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