Title:
【発明の名称】新規免疫抑制化合物
Document Type and Number:
Japanese Patent JP3095247
Kind Code:
B2
Abstract:
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
Inventors:
Armystead, David M.
Bowger, Joshua S.
Myers, Harold Veui.
Saunders, Jeffrey Oh.
Tongue, Roger Dee.
Bowger, Joshua S.
Myers, Harold Veui.
Saunders, Jeffrey Oh.
Tongue, Roger Dee.
Application Number:
JP51265591A
Publication Date:
October 03, 2000
Filing Date:
July 02, 1991
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/16; A61K31/165; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/395; A61K31/40; A61K31/401; A61K31/4025; A61K31/4427; A61K31/443; A61K31/4439; A61K31/445; A61K31/4525; A61K31/34; A61K31/453; A61K31/454; A61K31/4545; A61P25/02; A61P37/06; C07C233/56; C07C235/12; C07C235/34; C07D207/08; C07D207/16; C07D211/60; C07D307/54; C07D317/60; C07D333/24; C07D401/06; C07D401/12; C07D403/06; C07D405/06; C07D409/06; (IPC1-7): A61K31/16; A61K31/165; A61K31/343; A61K31/401; A61K31/445; A61P25/02; A61P37/06
Other References:
Ｊ．Ｏｒｇ．Ｃｈｅｍ．，Ｖｏｌ．５３，Ｎｏ．１９（１９８８）ｐ．４６４３−４６４４
Attorney, Agent or Firm:
Yoshinori Hosoda