Title:
【発明の名称】メタロプロテアーゼ阻害剤としての新規な大環状化合物
Document Type and Number:
Japanese Patent JP2001524949
Kind Code:
A
Abstract:
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
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Inventors:
Shui, Chu-Pio.
Desicco, curl, pee.
Charney, Robert, Jay.
Arner, Elizabeth.
Degrad, William, F.
Tuan, Jin Woo.
Whoa, Shiah.
Jacobson, Irina, Sipora.
Magorda, Ronald, El.
Nelson, David.
Desicco, curl, pee.
Charney, Robert, Jay.
Arner, Elizabeth.
Degrad, William, F.
Tuan, Jin Woo.
Whoa, Shiah.
Jacobson, Irina, Sipora.
Magorda, Ronald, El.
Nelson, David.
Application Number:
JP53993598A
Publication Date:
December 04, 2001
Filing Date:
May 14, 1998
Export Citation:
Assignee:
DuPont Pharmaceuticals Company
International Classes:
A61K31/395; A61K31/422; A61K31/427; A61K31/4427; A61K31/4523; A61K31/496; A61K31/5377; A61P1/02; A61P1/14; A61P7/02; A61P7/04; A61P19/02; A61P21/00; A61P25/32; A61P27/02; A61P27/06; A61P29/00; A61P31/18; A61P37/06; A61P43/00; C07D245/02; C07D255/02; C07D267/00; C07D273/02; C07D291/02; C07D401/12; C07D403/12; C07D413/06; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D419/12; C07D498/08; C07D521/00; C07K5/06; C07K5/065; C07K5/078; C12Q1/37; A61K38/00; (IPC1-7): C07D273/02; A61K31/395; A61K31/422; A61K31/427; A61K31/4427; A61K31/4523; A61K31/496; A61K31/5377; A61P1/02; A61P1/14; A61P7/02; A61P7/04; A61P19/02; A61P21/00; A61P25/32; A61P27/02; A61P27/06; A61P29/00; A61P31/18; A61P37/06; A61P43/00; C07D413/06; C07D413/12; C07D417/12; C07D417/14
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)