【発明の名称】新規なマロン酸誘導体、その調製方法、その使用およびそれを含有する医薬組成物(Xa因子活性阻害) - Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung

Title:

【発明の名称】新規なマロン酸誘導体、その調製方法、その使用およびそれを含有する医薬組成物(Xa因子活性阻害)

Document Type and Number:

Japanese Patent JP2002534420

Kind Code:

A

Abstract:

New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I,wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in the claims. The compounds of formula I are inhibitors of the blood clotting enzyme factor Xa. Processes for the preparation of the compounds of formula I, methods of inhibiting factor Xa activity and of inhibiting blood clotting, use of the compounds of formula I in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of factor Xa activity such as thromboembolic diseases, and use of the compounds of formula I in the preparation of medicaments to be applied in such diseases. Compositions containing a compound of formula I in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula I together with pharmaceutically acceptable carrier substances and auxiliary substances.

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Inventors:

Elizabeth Defosa
Uwe Heinert
Otomar Klingler
Gerhard zohler
Hans Matter
Fahd Ai Al-Obaydi
Armin Walther
Peter Wilde Goose

Application Number:

JP2000592279A

Publication Date:

October 15, 2002

Filing Date:

December 23, 1999

Export Citation:

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Assignee:

Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung

International Classes:

A61K31/16; A61K31/44; A61K31/445; A61K31/495; A61K31/5375; A61P7/02; A61P9/00; A61P43/00; C07C231/02; C07C233/47; C07C257/18; C07C279/14; C07C303/40; C07C311/39; C07D213/73; C07D257/12; C07D295/04; C07D295/10; C07D295/14; C07D295/18; C07D295/20; (IPC1-7): C07C233/47; A61K31/16; A61K31/44; A61K31/445; A61K31/495; A61K31/5375; A61P7/02; A61P9/00; A61P43/00; C07C231/02; C07C303/40; C07C311/39; C07D213/73; C07D295/10; C07D295/14; C07D295/18; C07D295/20

Attorney, Agent or Firm:

Chika Takagi (2 outside)

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