Title:
【発明の名称】多くの類似化合物を製造するための新規固相合成法
Document Type and Number:
Japanese Patent JP2001509809
Kind Code:
A
Abstract:
This application relates to a process for synthesizing multiple analogous compounds, which process comprises: (a) reacting a solid-phase supported intermediate with a cleaving/condensing reagent by a means which results in the formation of a solution-phase condensation product and affords remainder solid-phase supported intermediate; (b) separating the solution-phase condensation product formed by step (a) from the solid-phase; (c) reacting remainder solid-phase supported intermediate with a cleaving/condensing reagent distinct from the cleaving/condensing reagent applied in step (a) to give a solution-phase condensation product analogous to the solution-phase condensation product formed by step (a); (d) separating the solution-phase condensation product formed by step (c) from the solid-phase; and (e) optionally repeating process steps (c) and (d) one or more additional times, if remainder solid-phase supported intermediate is present, using a further distinct cleaving/condensing reagent for each repetition to give additional analogous solution-phase.
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Inventors:
Ferran, john christopher
Application Number:
JP53312798A
Publication Date:
July 24, 2001
Filing Date:
January 29, 1998
Export Citation:
Assignee:
Axis Pharmaceuticals, Incorporated
International Classes:
C07B61/00; C07C231/02; C07C237/22; C07C245/08; (IPC1-7): C07B61/00; C07C231/02; C07C237/22; C07C245/08
Attorney, Agent or Firm:
Takashi Ishida (4 others)