Title:
【発明の名称】ラジカル親和性の置換分を有する新規ステロイド、その製造法および該化合物を含有する医薬
Document Type and Number:
Japanese Patent JP2828780
Kind Code:
B2
Abstract:
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel substituted steroid compounds can be made from steroids having an estrane, androstane, pregnane or cholestane basic skeleton and have a radical-attracting aromatic substituent of the general formula -(CH2)nX, or =CH-(CH2)mX at the 17 or 6 position of the steroid nucleus, wherein X=Y, OY, SY, SeY or NHY; n=0 to 5; m=n-1 and Y is a phenyl group having five substituents A, B, C, D and E, wherein A to E is independently H, alkyl, Oalkyl, Oacyl, OH, or one of the substituents B, C or D is NR2 wherein R=alkyl and each of the other substituents is hydrogen. Pharmaceutical compositions containing the novel substituted steroid compounds and methods of making them are also part of the invention.
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Inventors:
DOROESHAA PEETAA
MENZENBATSUHA BERUNTO
HONSORUDO KURUTO
UNDOITSU BERUNTO
OETERU MIHYAERU
REEMAA BORUFUGANGU
KAUFUMAN GYUNTAA
SHUREEDAA IENSU
MENZENBATSUHA BERUNTO
HONSORUDO KURUTO
UNDOITSU BERUNTO
OETERU MIHYAERU
REEMAA BORUFUGANGU
KAUFUMAN GYUNTAA
SHUREEDAA IENSU
Application Number:
JP51352895A
Publication Date:
November 25, 1998
Filing Date:
November 08, 1994
Export Citation:
Assignee:
IENAFUARUMU GMBH
International Classes:
A61P29/00; C07J1/00; C07J31/00; C07J41/00; C07J51/00; A61K31/56; (IPC1-7): C07J31/00; A61K31/56; C07J1/00; C07J41/00; C07J51/00
Attorney, Agent or Firm:
Nobuto Watanabe (1 person outside)