Title:
【発明の名称】新規な置換コハク酸系メタロ-β-ラクタマーゼ阻害薬およびそれの細菌感染治療での使用
Document Type and Number:
Japanese Patent JP2003527332
Kind Code:
A
Abstract:
This invention relates to novel substituted succinic acid metallo-beta-lactamase inhibitors which are useful potentiators of beta-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a b-lactam antibiotic, a therapeutically effective amount of a compound of formula I: including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.
Inventors:
Barkovec, The Ames M
Green Lee, Mark Elle
Olson, Stephen H
Rouen, Gregory Pee
Green Lee, Mark Elle
Olson, Stephen H
Rouen, Gregory Pee
Application Number:
JP2001532588A
Publication Date:
September 16, 2003
Filing Date:
October 27, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D233/60; A61K31/194; A61K31/407; A61K31/4164; A61K31/4985; A61K45/00; A61P31/04; A61P43/00; C07C57/38; C07C57/58; C07C59/64; C07C69/612; C07C69/734; C07C229/34; C07C257/14; C07C271/22; C07C279/14; C07D307/91; C07D333/20; C07D405/06; C07D409/06; C07D487/18; C07D521/00; (IPC1-7): C07C229/34; A61K31/194; A61K31/407; A61K31/4164; A61K31/4985; A61K45/00; A61P31/04; A61P43/00; C07C257/14; C07C271/22; C07C279/14; C07D233/60; C07D487/18
Domestic Patent References:
| JPH02256654A | 1990-10-17 | |||
| JPS63208596A | 1988-08-30 | |||
| JPH10279990A | 1998-10-20 | |||
| JPS4519779B1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)