Title:
【発明の名称】新規合成カテコール誘導体、その製造方法及びその使用方法
Document Type and Number:
Japanese Patent JP2000514042
Kind Code:
A
Abstract:
Catechol derivatives of general formula (I)in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negative bacteria. Conjugates with antibiotics improve penetration into bacterial cells, thereby increasing antibacterial efficacy of the cells.
Inventors:
Hanish Rotal
Mailman Ute
Schnaberlauf Matthias
Rice Broth Ralph
Mailman Ute
Schnaberlauf Matthias
Rice Broth Ralph
Application Number:
JP50216198A
Publication Date:
October 24, 2000
Filing Date:
May 14, 1997
Export Citation:
Assignee:
Grunenthal Gesellschaft Mito Beschlenktel Haftung
International Classes:
A61K31/195; A61K31/401; A61K31/43; A61K31/431; A61K31/545; A61K47/48; A61P3/00; A61P31/04; C07C233/81; C07C235/60; C07C235/64; C07C237/22; C07C245/08; C07C251/16; C07C251/24; C07C251/80; C07C251/86; C07D207/16; C07D263/06; C07D499/00; C07D499/68; C07D499/70; C07D501/00; C07D501/22; C07D501/24; C07D501/34; C07D501/46; (IPC1-7): C07C235/60; A61K31/401; A61K31/42; A61K31/43; A61K31/431; A61K31/545; A61P3/00; A61P31/04; C07C235/64; C07C245/08; C07C251/24; C07C251/86; C07D207/16; C07D263/06; C07D499/68; C07D499/70; C07D501/22
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)