Title:
【発明の名称】抗血栓作用を有するオリゴ糖混合物
Document Type and Number:
Japanese Patent JP2002502454
Kind Code:
A
Abstract:
A mixture of linear oligosaccharides containing different numbers of repeating sulphated disaccharide units derived from L-iduronic acid (IdoA) and N-acetyl-D-galactosamine (Gal-NAc) and having the following characteristics (a) a molecular weight in the range of 1600-20000 for 90% or more of the mixture, (b) a sulphur content of 6.0-8.0% by weight, (c) a sulphate/carboxylate ratio of 1.2-1.6, (d) a disulphated disaccharide content of 20-60% by weight of the mono-sulphated disaccharide content, and (e) an antithrombin activity of 20-60 IU/mg. The mixture may be used as an antithrombotic agent and is prepared by depolymerisation of dermatan sulphate by periodate oxidation, followed by borohydride reduction and acid hydrolysis and then ion exchange fractionation.
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Inventors:
Lundqvist, Mons
Johansen, Christian Bettn
Johansen, Christian Bettn
Application Number:
JP50140299A
Publication Date:
January 22, 2002
Filing Date:
May 15, 1998
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited Actiesel Scab (Lebens Chemisque Fabric Production Actiesl Scab)
International Classes:
A61K31/715; A61K31/737; A61P7/02; A61K31/726; A61P9/14; C08B37/00; C08B37/02; C08B37/08; C08L5/00; A61K; C08B; (IPC1-7): C08B37/08; A61K31/726; A61P7/02; C08B37/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)