Title:
【発明の名称】エストレン‐3,17‐ジオン誘導体の製法
Document Type and Number:
Japanese Patent JPS6030517
Kind Code:
B2
Abstract:
Estrene-3,17-diones of the formula wherein X is oxo, or ketalized oxo, preferably alkylenedioxy of 2-6 carbon atoms or o-phenylenedioxy; DELTA IS A CARBON ATOM LINKED TO THE ADJACENT CARBON ATOMS BY A DOUBLE BOND AND TWO SINGLE BONDS; R1 is methyl or ethyl, and R2 and R3 collectively are a carbon-to-carbon bond or methylene, useful as intermediates for the production of pharmacologically active steroids, are prepared by fermenting 18-ethyl-4-estrene-3,17-dione or 18-methyl-4-estrene-3,17-dione with a fungal culture of the genus Penicillium or Fusarium to produce the corresponding 15 alpha -hydroxy-steroid; IN EITHER ORDER, CONVERTING THE HYDROXY GROUP OF THE THUS-PRODUCED 15 alpha -HYDROXY STEROID TO A SULFONIC ACID ESTER THEREOF AND KETALIZING THE 3-KETO GROUP THEREOF; AND TREATING THE KETALIZED AND ESTERIFIED STEROID WITH A BASE TO FORM A DELTA 15-COMPOUND OR WITH DIMETHYLSULFOXONIUM METHYLIDE TO FORM A 15 beta ,16 beta -METHYLENE COMPOUND AND, OPTIONALLY, HYDROLYZING THE 3-KETAL GROUP.
Inventors:
KAARU PETSUORUTO
RUUDORUFU UIIHIERUTO
RUUDORUFU UIIHIERUTO
Application Number:
JP14105675A
Publication Date:
July 17, 1985
Filing Date:
November 25, 1975
Export Citation:
Assignee:
SCHERING AG
International Classes:
C12P33/12; C07J1/00; C07J21/00; C07J31/00; C07J53/00; C12R1/80; (IPC1-7): C12P33/12; C07J1/00
Attorney, Agent or Firm:
Toshio Yano