Title:
【発明の名称】GABA受容体のリガンドであるピリド-ピリダジン誘導体
Document Type and Number:
Japanese Patent JP2003508531
Kind Code:
A
Abstract:
A class of pyrido[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 8-position, a substituted alkoxy moiety at the 2-position, and a range of substituents at the 3-position, are selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
Inventors:
Carling, William Robert
Castro Pinero, Jose Lewis
Mitsuchinson, Andrew
Street, Leslie Yogyov
Castro Pinero, Jose Lewis
Mitsuchinson, Andrew
Street, Leslie Yogyov
Application Number:
JP2001522224A
Publication Date:
March 04, 2003
Filing Date:
August 30, 2000
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/5025; A61P9/00; A61P9/10; A61P25/00; A61P25/08; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P31/18; A61P43/00; C07D471/04; (IPC1-7): C07D471/04; A61K31/5025; A61P9/00; A61P9/10; A61P25/08; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P31/18; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)