Title:
【発明の名称】低酸素症局在性残基を含有するレニウムおよびテクネチウム錯体
Document Type and Number:
Japanese Patent JP3385048
Kind Code:
B2
Abstract:
A compound of the formulae where at least one R is -(A)p -R2 where (A)p is a linking group and R2 is a hypoxia localizing noiety; and wherein the other R groups are the same, or different and are independently selected from hydrogen, halogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, aryl, -COOR3, -NH2, hydroxyalkyl, alkoxyalkyl, hydroxyaryl, haloalkyl, arylalkyl, -alkyl-COOR3, -alkyl-CON(R3)2, alkyl-N(R3)2, -aryl-COOR3, -aryl-CON(R3)2, -aryl-N(R3)2, 5- or 6-membered nitrogen- or oxygen-containing heterocycle; or two R groups taken together with the one or more atoms to which they are attached form a carbocyclic or heterocyclic, saturated or unsaturated spiro or fused ring which may be substituted with R groups; R1 is hydrogen, a thiol protecting group or -(A)p -R2; R3 is hydrogen, alkyl or aryl; m = 2 to 5; p = 0 to 20 A)
Inventors:
Karen Linder
Adrian Di Nan
David P. Nowotnik
Conder Lady Lamaringham
Richard Jay Di Rocco
William El Ramsey
John P. Piro
Adrian Di Nan
David P. Nowotnik
Conder Lady Lamaringham
Richard Jay Di Rocco
William El Ramsey
John P. Piro
Application Number:
JP29120492A
Publication Date:
March 10, 2003
Filing Date:
October 29, 1992
Export Citation:
Assignee:
Blackco International Besloten Fuennaught Shap
International Classes:
A61K31/555; A61K49/00; A61K51/04; A61P43/00; C01G47/00; A61K51/00; C07C251/34; C07C251/38; C07C323/24; C07D233/91; C07D307/71; C07F13/00; (IPC1-7): C07D307/71; A61K51/00; A61P43/00; C01G47/00
Domestic Patent References:
| JP4504129A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)