Title:
【発明の名称】治療学的抗潰瘍活性を有する化合物の合成方法
Document Type and Number:
Japanese Patent JPS63502903
Kind Code:
A
Abstract:
To synthesize molecules with antiulcer action, specifically ranitidine, niperotidine and cimetidine, having the formula: (V) wherein R1 is hydrogen or together with R2 represents the rest of a cycloaliphatic or heterocyclic optionally substituted ring with 5 or 6 carbon atoms, R2 represents H, alkyl, alkyl substituted with a simple or substituted aromatic ring or with a single or substituted heterocyclic ring, Ar represents a simple or substituted phenyl group, a simple or substituted heterocyclic aromatic group, N=1, 2, 3, 4, 5 or 6 and X represents CH-NO2, S, N-C 3BOND N, the compound (II) is prepared through the following process sequence: (II) +TR wherein Z=H, NO2, halogen and R3=-(CH2)n Ar, -(CH2)n -SH, -(CH2)n-S-S-(CH2)n, -(CH2)n-S-CH2Ar Y being halogen. The urea of formula (II) is converted in a first stage into the corresponding carbodiimide (VI) by reaction with triphenylphosphine and bromine in the presence of a strong base and in a second stage is obtained the desired compound by reaction with nitromethane or with a saline derivative of cynamide.
Inventors:
Rainer, Albert
Application Number:
JP50225887A
Publication Date:
October 27, 1988
Filing Date:
March 27, 1987
Export Citation:
Assignee:
Jianus Halmatie Uteisi SRL
International Classes:
C07C335/06; C07C67/00; C07C313/00; C07C323/25; C07C323/44; C07C325/00; C07D233/64; C07D307/52; C07D317/58; C07D407/00; C07D407/12; (IPC1-7): C07C149/273; C07C149/437; C07C157/02; C07D233/64; C07D307/52; C07D407/12
Attorney, Agent or Firm:
Heiyoshi Odashima