【発明の名称】アリルオキシプロパノ-ルアミン類及びアリルエタノ-ルアミン類の合成法

Japanese Patent JPS63502585

A

A process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula (1) or (2) wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl or WB wherein W is a straight or branched chain alkylene of from 1 to about 6 carbon atoms and wherein B is -NR2COR3, -NR2CONR3R4, -NR2SO2R3, -NR2SO2NR3R4, or -NR2COOR5, where R2, R3, R4, and R5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynil, aryl, heteroaryl, or aralkyl, except that R3 and R5 are not hydrogen when B is -NR2SO2R3 or -NR2COOR5, or R3 and R4 may together with N form a 5- to 7-membered heterocyclic group. The process can be used to prepare beta-blocking agents, useful in the treatment of cardiac conditions.

Patel, Guernshire
May, Quong H. X
Mattier, William El

JP50013687A

September 29, 1988

November 14, 1986

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The DuPont Merck Pharmaceuticals Company

C07B43/04; C07B31/00; C07C41/00; C07C41/22; C07C43/23; C07C67/00; C07C213/00; C07C213/02; C07C217/30; C07C217/32; C07C231/00; C07C231/12; C07C233/36; C07C233/38; C07C233/40; C07C233/62; C07C235/08; C07C235/28; C07C239/00; C07C301/00; C07C303/40; C07C313/00; C07C317/32; C07D209/08; C07D209/16; C07D209/88; C07D235/26; C07D237/20; C07D239/54; C07D261/08; C07D285/10; C07D303/00; C07D303/22; C07D307/68; C07D307/88; C07D405/12; C07D417/00; C07D473/00; C07D493/00; (IPC1-7): C07/; C07B43/04; C07C89/00; C07C91/16; C07C93/06; C07C102/00; C07C103/26; C07C103/44; C07C103/64; C07C103/737; C07C103/82; C07C125/063; C07C127/17; C07C127/19; C07C143/72; C07C143/86; C07C145/00; C07D209/08; C07D209/16; C07D209/88; C07D235/26; C07D237/20; C07D239/54; C07D261/08; C07D285/10; C07D295/18; C07D303/22; C07D307/68

Akira Asamura (2 outside)

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