Title:
【発明の名称】タキソール誘導体、その薬剤組成物および調製法
Document Type and Number:
Japanese Patent JPH04504845
Kind Code:
A
Abstract:
Derivatives of taxol represented by the formula (II) wherein R and R' are each H or the residue of an amino acid selected from the group consisting of alanine, leucine, isoleucine, saline, phenylalanine, proline, lysine and arginine or a group of the formula (III) wherein n is an integer of 1 to 3 and R2 and R3 are each hydrogen on an alkyl radical having from one to three carbon atoms or wherein R2 and R3 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring having four to five carbon atoms, with the proviso that at least one of R and R1 is not hydrogen, are provided together with pharmaceutical compositions of such derivatives. The taxol derivatives have increased water solubility as compared to taxol, and have excellent antitumor activity.
Inventors:
Stella Valentino Jay
Mathieu Abraham Yi.
Mathieu Abraham Yi.
Application Number:
JP50391190A
Publication Date:
August 27, 1992
Filing Date:
March 09, 1990
Export Citation:
Assignee:
University of Kansas
International Classes:
A61K31/335; A61K31/337; A61K31/40; A61K31/435; A61P35/00; C07D305/14; (IPC1-7): A61K31/335; A61K31/40; A61K31/435; C07D305/14
Attorney, Agent or Firm:
Eijiro Tanikawa