Title:
【発明の名称】脂質膜を横切る輸送のための膜透過性構築物
Document Type and Number:
Japanese Patent JP2002511885
Kind Code:
A
Abstract:
Constructs of peptides and nucleic acid analogs conjugated together for transport across a lipid membrane and for delivery into interactive contact with intracellular polynucleotides are disclosed. Transport is effected through at least the exterior membrane of a cell, and most likely also through the walls of subcellular structures separated from the cytosol by lipid membranes, including the nucleus, mitochondria, ribosomes, etc. Peptide nucleic acid (PNA) analog sequences conjugated through a labile disulfide bond to transporting peptides, are intracellulary cleaved, and target mRNA (antigene) or dsDNA (antisense).
Inventors:
Langel, Uro
Bad Phi, Tamas
Puga, Margus
Barkuna, Andres
Sole, click
Halbling, Mathias
Bad Phi, Tamas
Puga, Margus
Barkuna, Andres
Sole, click
Halbling, Mathias
Application Number:
JP50991099A
Publication Date:
April 16, 2002
Filing Date:
July 16, 1998
Export Citation:
Assignee:
The Perkin-Elmer Corporation
International Classes:
A61K47/42; A61K31/712; A61K38/00; A61K47/48; A61K48/00; C07K14/00; C07K14/435; C07K14/575; C12N15/113; C12N15/87; (IPC1-7): A61K38/00; A61K47/42; A61K47/48; A61K48/00; C07K14/00
Attorney, Agent or Firm:
Shusaku Yamamoto