PYRROLO(3,2,1-IJ)QUINOLINE-5-CARBOXYLIC ACID DERIVATIVE

Title:

PYRROLO(3,2,1-IJ)QUINOLINE-5-CARBOXYLIC ACID DERIVATIVE

Document Type and Number:

Japanese Patent JPS5978189

Kind Code:

A

Abstract:

NEW MATERIAL:The compound of formula I (R1 is lower alkyl; R2 is H, lower alkyl, or lower alkanoyl; R3 is lower alkyl; X is halogen; n is 1 or 2).

EXAMPLE: 9- ( 3-Methylamino-1-pyrrolidinyl ) -8-fluoro-2-methyl-1, 2-dihydro-6-oxo- pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid.

USE: Antibacterial agent for the infectious diseases of the urinary tract. It has excellent antibacterial activity especially to Gram-positive bacteria, glucose-unfermenting bacteria, tuberculous bacilli, and antibiotic-resistant bacteria.

PROCESS: The objective compound can be prepared e.g. by reacting the compound of formula II (R4 is halogen, lower alkanesulfonyloxy, etc.) with nearly equimolar amount of the compound of formula III in an inert solvent (e.g. dimethyl sulfoxide) preferably under the pressure of 1W10atom at 100W200°C for 1W20hr.

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Inventors:

ISHIKAWA HIROSHI
UNO TETSUYUKI
MIYAMOTO HISASHI
NAKAGAWA KAZUYUKI

Application Number:

JP18844382A

Publication Date:

May 04, 1984

Filing Date:

October 26, 1982

Export Citation:

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Assignee:

OTSUKA PHARMA CO LTD

International Classes:

C07D471/06; A61K31/47; A61P31/04; A61P31/06; (IPC1-7): A61K31/47; C07D471/06

Foreign References:

DE3144455A1

1982-06-24

Attorney, Agent or Firm:

Eiji Saegusa

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