PURPOSE: To provide the titled drug preparation effective for the remedy of thrombotic diseases, etc. by using dried urokinase as a main component, and compounding the component with a stabilizer composed of an inorganic salt and/ or an organic acid salt and albumin.
CONSTITUTION: The objective dried urokinase preparation is obtained by using dried urokinase as a main component, and compounding a stabilizer containing 30W50mg of albumin and 10W20mg of an inorganic salt and/or organic acid salt per 100,000W30,000 IU of urokinase. The combined use of the components results in the synergistic stabilization of the dried urokinase. Since the stabilizer is effective also for the prevention of the decomposition of urokinase by freeze-drying, it is preferable to add the stabilizer prior to the freeze-drying of urokinase. The albumin is preferably those derived from human, and its purity is preferably ≥80% determined by electrophoresis.
NARITA SHIYUUSAKU
KONDOU MASAHIDE
ISHIKAWA SHIYOUICHI
| JPS54147916A | 1979-11-19 |