Title:
MANUFACTURE OF 3-CARBOXY-1-METHYLPYRROL-2- ACETIC ACID
Document Type and Number:
Japanese Patent JPS5973566
Kind Code:
A
Abstract:
A process for the preparation of 3-carboxyl-1-methylpyrrol-2-acetic acid of formula (I): and alkali metal salts thereof, comprises reacting acetone-bicarboxylic acid or an alkali metal salt thereof in an aqueous medium with methylamine and a halo-acetaldehyde, preferably chloroacetaldehyde, at a temperature from about 5 DEG C to about 25 DEG C. The resulting product is an intermediate suitable for organic syntheses, in particular for the preparation of 5-arylolyl-pyrrol-alkanoic acids which are known anti-inflammatory agents in the pharmaceutical field.
Inventors:
JIYORUJIYO BOTSUTATSUCHIO
SUTEFUANO KAMUPORUMI
BITSUTORIO KARURETSUTEI
MARUCHIERURO MARUKI
SUTEFUANO KAMUPORUMI
BITSUTORIO KARURETSUTEI
MARUCHIERURO MARUKI
Application Number:
JP16952983A
Publication Date:
April 25, 1984
Filing Date:
September 16, 1983
Export Citation:
Assignee:
MONTEDISON SPA
International Classes:
C07D207/34; (IPC1-7): C07D207/34
Attorney, Agent or Firm:
Motohiro Kurauchi
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