NEW MATERIAL:p-Hydroxyphenylglycine.α-phenylethanesulfonic acid salt.
EXAMPLE: D-p-hydroxyphenylglycine.(+)-α-phenylethanesulfohic acid salt.
USE: Raw material for preparation of D-p-hydroxyphenylglycine which is a raw material of semisynthetic penicillin and semisynthetic cephalosporin, and L-p- hydroxyphenylglycine useful as a remedy for ischemic cardiopathy, cardiac insufficiency and diabetes.
PROCESS: An optically active isomer of a compound selected from p-hydroxyphenylglycine and α-phenylethanesulfonic acid is made to react with reacemate of the other compound. One of the optically active p-hydroxyphenylglycine. optically active α-phenylethanesulfonic acid salt which is a hardly soluble diastereomer is separated and collected taking advantage of the solubility difference between two kinds of diastereomers produced by the above reaction.
YAMADA SHIGEKI
HONGOU CHIKARA
YOSHIOKA RIYUUZOU
Next Patent: PREPARATION OF OPTICALLY ACTIVE P-HYDROXYPHENYLGLYCINE