Title:
ACID ANHYDRIDE AS SPEED CONTROLLING AGENT FOR INVADING POLYMER CONTAINING USEFUL SUBSTANCE DISPERSED IN POLYMER MOTHER BODY OR POLYMER MOTHER BODY SURROUNDING USEFUL SUBSTANCE
Document Type and Number:
Japanese Patent JPS5925314
Kind Code:
A
Abstract:
The invention relates to the use of an acid anhydride incorporated as a latentiated catalyst in poly(ortho ester) and other polymers such that upon exposure to aqueous environments the acid anhydride generates the corresponding acid which catalyzes the matrix erosion. The releasing rate of a loaded drug or other beneficial substance incorporated into or surrounded by the poly(ortho ester) or other polymers can be controlled in that the drug is released as the poty(ortho ester)s or other polymer is eroded by action of the acid anhydride incorporated therein.
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Inventors:
TAKERU HIGUCHI
KENESU JIEE HIMUMERUSUTAIN
KENESU JIEE HIMUMERUSUTAIN
Application Number:
JP11945883A
Publication Date:
February 09, 1984
Filing Date:
June 30, 1983
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A01N25/10; A61K9/00; A61K9/20; C08K5/00; A61K9/22; A61K9/26; A61K47/00; A61K47/34; C08G65/00; C08G67/04; C08K5/09; C08L59/00; C08L67/00; C08L71/00; C08L71/02; C08L73/02; (IPC1-7): A61K9/00; C08K5/09; C08L59/00
Attorney, Agent or Firm:
Masao Okabe