Title:
MANUFACTURE OF 4-(2'-NITROPHENYL)-2,6- DIMETHYL-3,5-DICARBMETHOXY-1,4-DIHYDRO-PYRIDINE
Document Type and Number:
Japanese Patent JPS5839663
Kind Code:
A
Abstract:
In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20 DEG and 150 DEG C. The compound is a valuable medicine for the treatment of angina pectoris.
Inventors:
BURANKO IENKO
IGOORU RANGOFU
IGOORU RANGOFU
Application Number:
JP14276882A
Publication Date:
March 08, 1983
Filing Date:
August 19, 1982
Export Citation:
Assignee:
LEK TOVARNA FARMACEVTSKIH
International Classes:
A61K31/4418; A61K31/4422; A61P9/10; B01J31/00; C07D211/90; (IPC1-7): C07D211/90
Attorney, Agent or Firm:
Shigeru Yagita
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