Title:
THIALKANOYL-CARNITINE DERIVATIVE, MANUFACTURE AND MEDICINE
Document Type and Number:
Japanese Patent JPS58113172
Kind Code:
A
Abstract:
Thioalkanoyl-carnitines of general formula (I) wherein R is a straight alkylene radical having from 2 to 6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms, R1 is a straight or branched lower alkyl radical having from 1 to 4 carbon atoms, and X- is a halogen anion are prepared by reacting a thio-acid (II) of general formula R1COSH (a) if in (I) the thioalkanoyl radical R1COS- is in terminal position, with a compound of general formula (III) wherein n is an integer comprised between 0 and 4 or (b) if in (I) the thioalkanoyl radical R1COS- is not in terminal position, with a compound of general formula (IV) wherein m and m1 are integers comprised between 0 and 3, and R2 is a lower alkyl radical having from 1 to 4 carbon atoms. The pharmaceutical compositions containing the thioalkanoyl-carnitines (I) possess mucolytic and antitussive activity.
Inventors:
KURAUJIO KABATSUTSUA
MARIA ORUNERA CHINCHI
MARIA ORUNERA CHINCHI
Application Number:
JP21207382A
Publication Date:
July 05, 1983
Filing Date:
December 01, 1982
Export Citation:
Assignee:
SIGMA TAU IND FARMACEUTI
International Classes:
C07C327/28; A61K31/14; A61K31/205; A61K31/255; A61K31/265; A61P11/00; A61P11/14; C07C67/00; C07C325/00; C07C327/22; C07D405/06; A61K; C07C; (IPC1-7): C07C153/09
Domestic Patent References:
| JPS56130419A | 1981-10-13 | |||
| JPS5471024A | 1979-06-07 | |||
| JPS5579821A | 1980-06-16 |
Attorney, Agent or Firm:
Sota Asahina