Title:
官能基により修飾された二次代謝産物を生産する形質転換体および新規生合成遺伝子
Document Type and Number:
Japanese Patent JP4156235
Kind Code:
B2
Abstract:
An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing a gene involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof.
Inventors:
Koji Yanai
Kaoru Okakura
Shohei Yasuda
Watanabe Manabu
Miyamoto Koichi
Miki Naoki
Ken Murakami
Kaoru Okakura
Shohei Yasuda
Watanabe Manabu
Miyamoto Koichi
Miki Naoki
Ken Murakami
Application Number:
JP2001526925A
Publication Date:
September 24, 2008
Filing Date:
September 29, 2000
Export Citation:
Assignee:
Meiji Seika Co., Ltd.
International Classes:
C12N15/09; C07K11/00; C12N5/10; C12N9/02; C12N9/88; C12N9/90; C12N15/52; C12P13/00; C12P21/02; C12R1/645
Domestic Patent References:
| JP10502532A |
Other References:
Microbiology,1996年,vol.142, no.6,p.1345-1355
Mol Microbiol.,1997年,vol.23, no.2,p.191-202
化学と生物,2006年,vol.44, no.4,p.222-224
Mol Microbiol.,1997年,vol.23, no.2,p.191-202
化学と生物,2006年,vol.44, no.4,p.222-224
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota