Title:
複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
Document Type and Number:
Japanese Patent JP4215172
Kind Code:
B2
Abstract:
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that includes plural variable (VH and V kappa ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
Inventors:
Jacobo Bits Aya
Kucharapati Raju
Craforz Sue
Mendes Michael
Green rally
Kucharapati Raju
Craforz Sue
Mendes Michael
Green rally
Application Number:
JP52590998A
Publication Date:
January 28, 2009
Filing Date:
December 03, 1997
Export Citation:
Assignee:
Amgen Fremont Ink.
International Classes:
A01K67/027; C07K14/415; C07K16/00; C07K16/18; C07K16/24; C07K16/28; C12N5/08; C12N15/09; C12N15/85; C12P21/08; A61K39/00
Other References:
Nature Genetics, vol.7, pp.13-21 (1994)
Genomics, vol.26, pp.294-307 (1995)
Genomics, vol.26, pp.294-307 (1995)
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Toshi Gobe
Koichi Niimi