Title:
ビス[チオヒドラジドアミド]化合物の遷移金属錯体
Document Type and Number:
Japanese Patent JP2012506443
Kind Code:
A
Abstract:
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I), or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. In one embodiment, the compound is represented by Structural Formula (II), or a prodrug, isomer, ester, salt, hydrate, solvate or polymorph thereof. The present invention also provides a pharmaceutical composition comprising the compound of the invention and method of use thereof.
Inventors:
Masami Nagai
Shen Jen Hua
Shen Jen Hua
Application Number:
JP2011533295A
Publication Date:
March 15, 2012
Filing Date:
October 21, 2009
Export Citation:
Assignee:
Shinta Pharmaceuticals Corporation
International Classes:
C07F1/08; A61K31/28; A61K31/282; A61K31/295; A61K31/30; A61K31/315; A61K31/337; A61K45/00; A61P1/16; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P27/02; A61P35/00; A61P35/02; A61P37/02; C07C327/56; C07F15/04
Foreign References:
WO2007021881A1 | 2007-02-22 |
Other References:
JPN7013003529; Spectrochimica Acta Vol.42A, No.4, 1986, 507-513
JPN5012001682; SINGH: 'ANTITUMOUR AND IMMUNOMODULATORY EFFECTS OF CU(II) COMPLEXES OF THIOBENZHYDRAZIDE' METAL-BASED DRUGS V9 N1-2, 2002, P109-118
JPN5012001682; SINGH: 'ANTITUMOUR AND IMMUNOMODULATORY EFFECTS OF CU(II) COMPLEXES OF THIOBENZHYDRAZIDE' METAL-BASED DRUGS V9 N1-2, 2002, P109-118
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto