ビス[チオヒドラジドアミド]化合物の遷移金属錯体

Title:

ビス[チオヒドラジドアミド]化合物の遷移金属錯体

Document Type and Number:

Japanese Patent JP2012506444

Kind Code:

A

Abstract:

The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.

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Inventors:

Masami Nagai
Shen Jen Hua

Application Number:

JP2011533298A

Publication Date:

March 15, 2012

Filing Date:

October 21, 2009

Export Citation:

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Assignee:

Shinta Pharmaceuticals Corporation

International Classes:

C07C327/56; A61K31/28; A61K31/282; A61K31/295; A61K31/30; A61K31/315; A61P35/00; C07C327/00; C07F1/08; C07F15/04

Foreign References:

WO2007021881A1

2007-02-22

Other References:

JPN7013003530; Ｓｐｅｃｔｒｏｃｈｉｍｉｃａ　ＡｃｔａＶｏｌ．４２Ａ，　Ｎｏ．４, 1986, ５０７-５１３
JPN5012001682; ＳＩＮＧＨ: 'ＡＮＴＩＴＵＭＯＵＲ　ＡＮＤ　ＩＭＭＵＮＯＭＯＤＵＬＡＴＯＲＹ　ＥＦＦＥＣＴＳ　ＯＦ　ＣＵ（ＩＩ）　ＣＯＭＰＬＥＸＥＳ　ＯＦ　ＴＨＩＯＢＥＮＺＨＹＤＲＡＺＩＤＥ' ＭＥＴＡＬ-ＢＡＳＥＤ　ＤＲＵＧＳＶ９　Ｎ１-２, 2002, Ｐ１０９-１１８

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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