アミロイド症の治療法 - BELLUS HEALTH(INTERNATIONAL) LIMITED

Title:

アミロイド症の治療法

Document Type and Number:

Japanese Patent JP4187072

Kind Code:

B2

Abstract:

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

Inventors:

Kisylbski robert
Suzalek Walter A.
Weaver donald

Application Number:

JP2004098346A

Publication Date:

November 26, 2008

Filing Date:

March 30, 2004

Export Citation:

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Assignee:

BELLUS HEALTH(INTERNATIONAL) LIMITED

International Classes:

A61K31/185; A61K45/00; A61K31/7016; A61K31/7024; A61K31/715; A61K31/737; A61K31/795; A61K38/00; A61K47/48; A61L33/08; A61P3/10; A61P25/00; A61P25/28; A61P43/00; C07H11/00; C07H15/04

Domestic Patent References:

JP1171638A
JP1019021A

Foreign References:

US5164295
WO1990009789A1
WO1989005646A1

Other References:

The Journal of Biological Chemistry,Vol.266,No.20,pages 12878-12883
Journal of Virology,Vol.67,No.2,pages 643-650
Biochimica et Biophysica Acta,Vol.998,No.3,pages 231-235
The Journal of Biological Chemistry,Vol.262,No.4,pages 1456-1460

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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