To induce desirable and useful change in a biological substance by introducing a biological system, etc., into an electrostatic field and adjusting the electrostatic field parameters.

A biological system, etc., containing a living organism such as microorganism, true fungi, vegetable, invertebrate and vertebrate is introduced into an electrostatic field and the electrostatic field parameters such as field intensity are adjusted to cause desirable and useful changes such as the promoted generation and growth, changed gene expression, changed form, increased stress resistance and changed population dynamic.