Title:
低強度集束超音波脈動（ＬＩＦＵＰ）デバイスを使用する変性認知症の処置
Document Type and Number:
Japanese Patent JP7237835
Kind Code:
B2
Abstract:
Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
Inventors:
Jordan, Sherry
Schaefer, Mark Evan
Cove, Alex
Worcester, Walter William
Schaefer, Mark Evan
Cove, Alex
Worcester, Walter William
Application Number:
JP2019532946A
Publication Date:
March 13, 2023
Filing Date:
December 14, 2017
Export Citation:
Assignee:
Brainsonics Corporation
International Classes:
A61N7/00
Foreign References:
| US20110270138 | ||||
| US20120197163 | ||||
| US20120296241 | ||||
| US20140188011 | ||||
| WO2015192189A1 | ||||
| US20160067526 |
Other References:
JORDAO, Jessica F. et al.,“Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound”,Experimental Neurology,(米),Elsevier Inc.,2013年,Vol. 248,p. 16-29
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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