Title:
左室拡張障害の治療薬
Document Type and Number:
Japanese Patent JP4603534
Kind Code:
B2
Abstract:
The present invention provides a drug serving as a muscular relaxation accelerating agent, a therapeutic agent for left ventricular diastolic dysfunction, a therapeutic agent for angina pectoris, a therapeutic agent for acute pulmonary edema, a drug for improving blood flow of microcirculatory system, a therapeutic and prophylactic agent for hypertension, a therapeutic and prophylactic agent for ventricular tachycardia and a therapeutic and prophylactic agent for torsade de pointes. A muscular relaxation accelerating agent comprising 1,4-benzothiazepine derivatives represented by the following general formula [I] or a pharmaceutically acceptable salt thereof as an active ingredient;
[wherein R 1 represents a hydrogen atom or C1-C3 lower alkoxy group; R 2 represents a hydrogen atom, C1-C3 lower alkoxy group or phenyl group (wherein the phenyl group may be substituted with 1 to 3 substituents selected from a group consisting of a hydroxyl group and a C1-C3 lower alkoxy group),
(wherein R 3 represents a C1-C3 acyl group); X represents -CO- or -CH 2 -, and n represents an integer of 1 or 2.] Said muscular relaxation accelerating agent is the drug to make muscle relax to treat left ventricular diastolic dysfunction, angina pectoris and acute pulmonary edema, and improve blood flow of microcirculatory system to treat and prevent hypertension and ventricular tachycardia. Further, it is an effective drug for treatment and prevention for torsade de pointes.
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Inventors:
Noboru Kaneko
Application Number:
JP2006512876A
Publication Date:
December 22, 2010
Filing Date:
April 28, 2005
Export Citation:
Assignee:
Aetas Pharma Co., Ltd.
International Classes:
A61K31/554; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P21/02; A61P43/00; C07D281/10; C07D417/06; C07D417/14
Domestic Patent References:
| JP2000247889A | 2000-09-12 | |||
| JPH04230681A | 1992-08-19 | |||
| JP2003095977A | 2003-04-03 |
Foreign References:
| US20040048780A1 | 2004-03-11 |
Attorney, Agent or Firm:
Takiguchi Shoji
Koichi Nakazato
Hitoshi Kawasaki
Koichi Nakazato
Hitoshi Kawasaki