Title:
TREATMENT METHOD USING NITROGEN MONOXIDE PRECURSOR
Document Type and Number:
Japanese Patent JP2013040176
Kind Code:
A
Abstract:
To provide a method for treatment or prevention of a nitric oxide production decrease caused by next-best urea cycle function.
A therapeutically effective amount of a nitrogen monoxide precursor selected from a group of citrulline, arginine, and combinations thereof is administered to a subject suffering from a disease related to a decreased production of urea cycle intermediate, or being exposed, or just anterior, to an environmental stimulation related to a decreased production of urea cycle intermediate. More specifically, the administration is transvenous or oral, and the next-optimal urea cycle function includes a decreased production of urea cycle intermediate.
Inventors:
SUMMAR MARSHALL L
CHRISTMAN BRIAN
BARR FREDERICK E
CHRISTMAN BRIAN
BARR FREDERICK E
Application Number:
JP2012201762A
Publication Date:
February 28, 2013
Filing Date:
September 13, 2012
Export Citation:
Assignee:
UNIV VANDERBILT
International Classes:
A61K45/00; A61K31/198; A61P1/04; A61P1/16; A61P9/12; A61P11/00; A61P11/06; A61P15/10; A61P29/00; A61P31/04; A61P43/00; C12N9/00; A61K38/00
Foreign References:
| US0001005A | 1838-11-12 | |||
| WO2000006151A1 | 2000-02-10 | |||
| WO2000073322A1 | 2000-12-07 | |||
| WO1994016740A1 | 1994-08-04 | |||
| AU3460500A | 2001-05-30 |
Other References:
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JPN7011003036; ＭＩＺＵＴＡＮＩ， Ｎ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｒｇｉｎｉｎｅ ａｎｄ ｃｉｔｒｕｌｌｉｎｅ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｌｙｓｉｎｕｒｉｃ ｐｒｏｔｅｉｎ ｉｎｔｏｌｅｒａｎｃｅ' ＴＯＨＯＫＵ ＪＯＵＲＮＡＬ ＯＦ ＥＸＰＥＲＩＭＥＮＴＡＬ ＭＥＤＩＣＩＮＥ ｖｏｌ． １４２, 1984, ｐ．１５-２４
JPN6011043966; ＭＩＴＡＮＩ， Ｙ． ｅｔ ａｌ: 'Ｐｒｏｌｏｎｇｅｄ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ａｍｅｌｉｏｒａｔｅｓ ｃｈｒｏｎｉｃ ｐｕｌｍｏｎａｒｙ ｈｙｐｅｒｔｅｎｓｉｏｎ ａｎｄ ｐｕｌｍｏｎａｒｙ ｖａｓｃ' ＣＩＲＣＵＬＡＴＩＯＮ ｖｏｌ．９６， ｎｏ．２, 1997, ｐ．６８９-６９７
JPN7011003037; ＡＭＩＮ， Ｈ． Ｊ． ｅｔ ａｌ: 'Ａｒｇｉｎｉｎｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｐｒｅｖｅｎｔｓ ｎｅｃｒｏｔｉｚｉｎｇ ｅｎｔｅｒｏｃｏｌｉｔｉｓ ｉｎ ｔｈｅ ｐｒｅｍａｔｕｒｅ ｉｎｆａｎｔ' ＪＯＵＲＮＡＬ ＯＦ ＰＥＤＩＡＴＲＩＣＳ ｖｏｌ．１４０， ｎｏ．４, 2002, ｐ．４２５-４３１
JPN7011003038; ＳＵＳＣＨＥＫ， Ｃ． Ｖ． ｅｔ ａｌ: 'Ｃｒｉｔｉｃａｌ ｒｏｌｅ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ｉｎ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｓｕｒｖｉｖａｌ ｄｕｒｉｎｇ ｏｘｉｄａｔｉｖｅ ｓｔｒｅｓｓ' ＣＩＲＣＵＬＡＴＩＯＮ ｖｏｌ．１０７， ｎｏ．２０, 2003, ｐ．２６０７-２６１４
JPN7011003039; ＤＡＧＥＮＡＩＳ， Ｃ． ｅｔ ａｌ: 'Ａｃｕｔｅ Ｌ-ａｒｇｉｎｉｎｅ ｓｕｐｐｌｅｍｅｎｔ ａｎｄ ｃａｒｄｉａｃ ｓｕｒｇｅｒｙ' ＣＡＮＡＤＩＡＮ ＪＯＵＲＮＡＬ ＯＦ ＡＮＡＥＳＴＨＥＳＩＡ ｖｏｌ．４３， ｎｏ．５ ＰＡＲＴ ２, 1996, ｐ．Ａ１６
JPN6011043972; ＨＯＪＯ， Ｆ． ｅｔ ａｌ: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｓｐｏｎｔａｎｅｏｕｓ ｐｕｌｍｏｎａｒｙ ｍｅｔａｓｔａｓｅｓ ｂｙ Ｌ-ａｒｇｉｎｉｎｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｉｎｄｕｃｔｉｏｎ ｏｆ ｃｙｔｏｔｏｘｉｃ' ＴＨＥ ＣＡＮＣＥＲ ＪＯＵＲＮＡＬ ｖｏｌ．３， ｎｏ．１, 1990, ｐ．１４-１９
JPN6011043976; ＧＡＲＤＩＮＥＲ， Ｋ． Ｒ． ｅｔ ａｌ: 'Ｒｅｄｕｃｅｄ ｉｎｔｅｓｔｉｎａｌ ａｂｓｏｒｐｔｉｏｎ ｏｆ ａｒｇｉｎｉｎｅ ｄｕｒｉｎｇ ｓｅｐｓｉｓ．' ＣＲＩＴＩＣＡＬ ＣＡＲＥ ＭＥＤＩＣＩＮＥ ｖｏｌ．２３， ｎｏ．７, 1995, ｐ．１２２７-１２３２
JPN6011043978; ＰＥＲＮＯＷ， Ｊ． ｅｔ ａｌ: 'Ｌ-Ａｒｇｉｎｉｎｅ ｐｒｏｔｅｃｔｓ ｆｒｏｍ ｉｓｃｈｅｍｉａ-ｒｅｐｅｒｆｕｓｉｏｎ-ｉｎｄｕｃｅｄ ｅｎｄｏｔｈｅｌｉａｌ ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ ｈｕｍａｎｓ ｉｎ ｖｉｖｏ．' ＪＯＵＲＮＡＬ ＯＦ ＡＰＰＬＩＥＤ ＰＨＹＳＩＯＬＯＧＹ ｖｏｌ．９５， ｎｏ．６, 2003, ｐ．２２１８-２２２２
JPN6011043981; ＡＫＩＳＵ， Ｍ． ｅｔ ａｌ: 'Ｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔ ｏｆ ｄｉｅｔａｒｙ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｗｉｔｈ Ｌ-ａｒｇｉｎｉｎｅ ａｎｄ Ｌ-ｃａｒｎｉｔｉｎｅ ｏｎ ｈｙｐｏｘｉａ／ｒｅｏｘｙｇｅｎａｔｉｏ' ＢＩＯＬＯＧＹ ＯＦ ＴＨＥ ＮＥＯＮＡＴＥ ｖｏｌ．８１， ｎｏ．４, 2002, ｐ．２６０-２６５
JPN6011043983; ＳＡＩＪＹＯ， Ｔ． ｅｔ ａｌ: 'Ａｕｔｏｎｏｍｉｃ ｎｅｒｖｏｕｓ ｓｙｓｔｅｍ ａｃｔｉｖｉｔｙ ｄｕｒｉｎｇ ｉｎｆｕｓｉｏｎ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ' ＬＩＶＥＲ ｖｏｌ．１８， ｎｏ．１, 1998, ｐ．２７-３１
JPN7011003036; ＭＩＺＵＴＡＮＩ， Ｎ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｒｇｉｎｉｎｅ ａｎｄ ｃｉｔｒｕｌｌｉｎｅ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｌｙｓｉｎｕｒｉｃ ｐｒｏｔｅｉｎ ｉｎｔｏｌｅｒａｎｃｅ' ＴＯＨＯＫＵ ＪＯＵＲＮＡＬ ＯＦ ＥＸＰＥＲＩＭＥＮＴＡＬ ＭＥＤＩＣＩＮＥ ｖｏｌ． １４２, 1984, ｐ．１５-２４
JPN6011043966; ＭＩＴＡＮＩ， Ｙ． ｅｔ ａｌ: 'Ｐｒｏｌｏｎｇｅｄ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ａｍｅｌｉｏｒａｔｅｓ ｃｈｒｏｎｉｃ ｐｕｌｍｏｎａｒｙ ｈｙｐｅｒｔｅｎｓｉｏｎ ａｎｄ ｐｕｌｍｏｎａｒｙ ｖａｓｃ' ＣＩＲＣＵＬＡＴＩＯＮ ｖｏｌ．９６， ｎｏ．２, 1997, ｐ．６８９-６９７
JPN7011003037; ＡＭＩＮ， Ｈ． Ｊ． ｅｔ ａｌ: 'Ａｒｇｉｎｉｎｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｐｒｅｖｅｎｔｓ ｎｅｃｒｏｔｉｚｉｎｇ ｅｎｔｅｒｏｃｏｌｉｔｉｓ ｉｎ ｔｈｅ ｐｒｅｍａｔｕｒｅ ｉｎｆａｎｔ' ＪＯＵＲＮＡＬ ＯＦ ＰＥＤＩＡＴＲＩＣＳ ｖｏｌ．１４０， ｎｏ．４, 2002, ｐ．４２５-４３１
JPN7011003038; ＳＵＳＣＨＥＫ， Ｃ． Ｖ． ｅｔ ａｌ: 'Ｃｒｉｔｉｃａｌ ｒｏｌｅ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ｉｎ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｓｕｒｖｉｖａｌ ｄｕｒｉｎｇ ｏｘｉｄａｔｉｖｅ ｓｔｒｅｓｓ' ＣＩＲＣＵＬＡＴＩＯＮ ｖｏｌ．１０７， ｎｏ．２０, 2003, ｐ．２６０７-２６１４
JPN7011003039; ＤＡＧＥＮＡＩＳ， Ｃ． ｅｔ ａｌ: 'Ａｃｕｔｅ Ｌ-ａｒｇｉｎｉｎｅ ｓｕｐｐｌｅｍｅｎｔ ａｎｄ ｃａｒｄｉａｃ ｓｕｒｇｅｒｙ' ＣＡＮＡＤＩＡＮ ＪＯＵＲＮＡＬ ＯＦ ＡＮＡＥＳＴＨＥＳＩＡ ｖｏｌ．４３， ｎｏ．５ ＰＡＲＴ ２, 1996, ｐ．Ａ１６
JPN6011043972; ＨＯＪＯ， Ｆ． ｅｔ ａｌ: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｓｐｏｎｔａｎｅｏｕｓ ｐｕｌｍｏｎａｒｙ ｍｅｔａｓｔａｓｅｓ ｂｙ Ｌ-ａｒｇｉｎｉｎｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｉｎｄｕｃｔｉｏｎ ｏｆ ｃｙｔｏｔｏｘｉｃ' ＴＨＥ ＣＡＮＣＥＲ ＪＯＵＲＮＡＬ ｖｏｌ．３， ｎｏ．１, 1990, ｐ．１４-１９
JPN6011043976; ＧＡＲＤＩＮＥＲ， Ｋ． Ｒ． ｅｔ ａｌ: 'Ｒｅｄｕｃｅｄ ｉｎｔｅｓｔｉｎａｌ ａｂｓｏｒｐｔｉｏｎ ｏｆ ａｒｇｉｎｉｎｅ ｄｕｒｉｎｇ ｓｅｐｓｉｓ．' ＣＲＩＴＩＣＡＬ ＣＡＲＥ ＭＥＤＩＣＩＮＥ ｖｏｌ．２３， ｎｏ．７, 1995, ｐ．１２２７-１２３２
JPN6011043978; ＰＥＲＮＯＷ， Ｊ． ｅｔ ａｌ: 'Ｌ-Ａｒｇｉｎｉｎｅ ｐｒｏｔｅｃｔｓ ｆｒｏｍ ｉｓｃｈｅｍｉａ-ｒｅｐｅｒｆｕｓｉｏｎ-ｉｎｄｕｃｅｄ ｅｎｄｏｔｈｅｌｉａｌ ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ ｈｕｍａｎｓ ｉｎ ｖｉｖｏ．' ＪＯＵＲＮＡＬ ＯＦ ＡＰＰＬＩＥＤ ＰＨＹＳＩＯＬＯＧＹ ｖｏｌ．９５， ｎｏ．６, 2003, ｐ．２２１８-２２２２
JPN6011043981; ＡＫＩＳＵ， Ｍ． ｅｔ ａｌ: 'Ｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔ ｏｆ ｄｉｅｔａｒｙ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｗｉｔｈ Ｌ-ａｒｇｉｎｉｎｅ ａｎｄ Ｌ-ｃａｒｎｉｔｉｎｅ ｏｎ ｈｙｐｏｘｉａ／ｒｅｏｘｙｇｅｎａｔｉｏ' ＢＩＯＬＯＧＹ ＯＦ ＴＨＥ ＮＥＯＮＡＴＥ ｖｏｌ．８１， ｎｏ．４, 2002, ｐ．２６０-２６５
JPN6011043983; ＳＡＩＪＹＯ， Ｔ． ｅｔ ａｌ: 'Ａｕｔｏｎｏｍｉｃ ｎｅｒｖｏｕｓ ｓｙｓｔｅｍ ａｃｔｉｖｉｔｙ ｄｕｒｉｎｇ ｉｎｆｕｓｉｏｎ ｏｆ Ｌ-ａｒｇｉｎｉｎｅ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ' ＬＩＶＥＲ ｖｏｌ．１８， ｎｏ．１, 1998, ｐ．２７-３１
Attorney, Agent or Firm:
Toru Ishikawa
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